Collagen is the most abundant vertebrate protein and forms a stable fibrous architecture in connective tissues, such as bone, cartilage, skin and tendon. Much recent research has been directed towards an understanding of the molecular and cellular mechanisms involved in the synthesis and degradation of collagen, because a change in the normal balance, or an increased destruction of collagen, can cause loss of function of specialized tissues. This short review attempts to summarize present knowledge about the proteolytic destruction of collagen (...) and the exciting new work on the factors that are emerging as important controlling agents. An understanding of the regulatory processes is yielding some important clues regarding the levels at which they can fail in pathological conditions and we speculate about evolving strategies for preventing uncontrolled resorption. (shrink)

The extant clinical literature indicates profound problems in the assessment, monitoring, and documentation of care in long-term care facilities. The lack of adequate resources to accommodate higher staff-to-resident ratios adds additional urgency to the goal of identifying more costeffective mechanisms to provide care oversight. The ever expanding array of electronic monitoring technologies in the clinical research arena demands a conceptual and pragmatic framework for the resolution of ethical tensions inherent in the use of such innovative tools. CareMedia is a project (...) that explores the utility of video, audio and sensor technologies as a continuous real-time assessment and outcomes measurement tool. In this paper, the authors describe the seminal ethical challenges encountered during the implementation phase of this project, namely privacy and confidentiality protection, and the strategies employed to resolve the ethical tensions by applying principles of the interest theory of rights. (shrink)

This book taps the best American thinkers to answer the essential American question: How do we sustain our experiment in government of, by, and for the people? Authored by an extraordinary and politically diverse roster of public officials, scholars, and educators, these chapters describe our nation's civic education problem, assess its causes, offer an agenda for reform, and explain the high stakes at risk if we fail.

A brief reference article on cultural relativism.

The opening sentence of Christopher Meyers’ Target Article is “Lying to one’s patient is wrong”. The author continues, “This truism is one that bioethicists have heartedly endorsed fo...

Now back in print, and in paperback, these two classic volumes illustrate the scope and quality of Royce'sthought, providing the most comprehensive selection ofhis writings currently available. They offer a detailedpresentation of the viable relationship Royce forgedbetween the local experience of community and thedemands of a philosophical and scientific vision ofthe human situation.The selections reprinted here are basic to any understandingof Royce's thought and its pressing relevanceto contemporary cultural, moral, and religious issues.

To paraphrase Lewis Carroll’s poem “The Walrus and the Carpenter” from his Through the Looking Glass, “The time has come to talk of many things.” Not as the Walrus did in the nursery rhyme, “of sho...

Books reviewed in this article: The Bible and Postmodern Imagination: Texts Under Negotiation. By Walter Brueggemann. In the Throe of Wonder: Intimations of the Sacred in a Post‐Modern World. By Jerome A. Miller. Interpreting Hebrew Poetry. By David L. Petersen and Kent Harold Richards. Exegetical Dictionary of the New Testament, Volume I: Aαρωυ‐Eυωχ. Edited by Horst Balz and Gerhard Schneiders. The Secretary in the Letters of Paul. By E. Randolph Richards. Revelation. By Wilfrid J. Harrington. Conversion to Christianity: Historical and (...) Anthropological Perspectives on a Great Transformation. Edited by Robert W. Hefner. The Metaphor of God Incarnate. By John Hick. Disputed Questions in Theology and the Philosophy of Religion. By John Hick. The Nature of God. By Gerard J. Hughes. The Animals Issue: Moral Theoy in Practice. By Peter Carruthers. Philosophy and Theology in the Middle Ages. By G. R. Evans. Modalities in Medieval Philosophy. By Simo Knuuttila. Da Descarres a Spinoza: Percorsi della teologia razionale nel seicento. By Maria Emanuela Scribano. Tra Descartes e Bayle: Poiret e la teodicea. By Gianluca Mori. Kierkegaard and the Limits of the Ethical. By Anthony Rudd. Kierkegaard on Art and Communication. Edited by George Pattison. Collected Works of Bernard Lonergan Volume 10: Topics in Education. Edited by Robert M. Doran and Frederick E. Crowe. A Theology of Reconstruction: Nation‐building and Human Rights. By Charles Villa‐Vicencio. Religious Methods and Resources in Bioethics. Edited by Paul F. Camenisch. Theological Developments in Bioethics. Edited by Andrew Lustig et al. Marriage in the Western Church: The Christianization of Marriage During the Patristic and Early Medieval Periods. By Philip L. Reynolds. Marriage in the Early Church. Translated and edited by David G. Hunter. The Clash of Gods: A Reinterpretation of Early Christian Art. By Thomas F. Mathews. A History of Religion in Britain: Practice and Belief from Pre‐Roman Times to the Present. Edited by Sheridan Gilley and W. J. Sheik. The Conversion of Henri IV: Politics, Power and Religious Belief in Early Modern France. By Michael Wolfe. English Polemics at the Spanish Court: Joseph Creswell's ‘Letter to the Ambassador from England’, The English and the Spanish Texts of 1606. Edited by Albert J. Loomie. (shrink)

Charles S. Peirce, William James, Josiah Royce, George Santayana, John Dewey, and George Herbert Mead: each of these individuals is an original and historically important thinker; each is an essential contributor to the period, perspective, and tradition of classical American philosophy; and each speaks directly, imaginatively, critically, and wisely to our contemporary global society, its distant possibilities for improvement, and its massive, pressing problems. From the initiative of pragmatism in approximately 1870 to Dewey's final work after World War II, (...) classical American philosophy has come to represent the critical articulation of attitudes, outlooks, and forms of life imbedded in the culture from which it arose. John Stuhr brings together the works of these foremost thinkers to present a comprehensive collection in American philosophy. Extensive introductory essays, written especially for this volume by leading scholars of the subject, provide not only the bibliographical and cultural contexts necessary to a full appreciation of each thinker, but also original critical and interpretive philosophical observations. (shrink)

A significant effect of China’s rejection of a planned economy for a free market is the stimulus this has given to discussion of therelationship between morality and the market. Some Chinese believe that the introduction of a market economy has had a negative effect on public morality. Others disagree and maintain that it has had only a positive effect. Besides this particular debate there are two others. In the first of these debates, it is maintained on the one side that (...) conduct in the market is amoral and essentially contractual or transactional in nature: a boundary must be drawn between economic conduct and conduct in other spheres of social life. Against this it is argued that ethical norms apply equally to all aspects of social life including the economy. In the second debate one side holds that the market engenders its own “ethical” norms. In opposition it is argued that the moral categories articulated in moral philosophy are applicable to behaviour in the market. (shrink)

The propositions that the senses are separate and that the global array may be sufficient for adequate perception are questioned. There is evidence that certain tasks may be primarily but these are a special case along the behavioral continuum. Many tasks involve sensory information that is ambiguous, and other sources of information may be required for adequate perception.

Engaging with phenomenology, moral philosophy, politics and psychology, and authored by an international team of leading scholars in the field, this volume explores the ethical and social significance of a variety of human emotions.

Francis Hutcheson's objections to psychological egoism usually appeal to experience or introspection. However, at least one of them is theological: It includes premises of a religious kind, such as that God rewards the virtuous. This objection invites interpretive and philosophical questions, some of which may seem to highlight errors or shortcomings on Hutcheson's part. Also, to answer the questions is to point out important features of Hutcheson's objection and its intellectual context. And nowhere in the scholarship on Hutcheson do we (...) find these questions addressed. This paper addresses them. A fact that emerges is that the apparent errors or shortcomings the questions may highlight are just that – apparent errors or shortcomings; in reality they are nothing of the kind. (shrink)

The authors of this volume — all of them recognized representatives of a wide range of academic disciplines — agree that Locke’s work must have had a considerable influence both on English and German literature and the visual arts of Great Britain, especially in the eighteenth and nineteenth centuries. From the perspective of interdisciplinarity and intertextuality, the essays presented here deal with Locke as a source of ideas for Archibald Alison, John Constable, Daniel Defoe, Henry Fielding, Oliver Goldsmith, Johann (...) Timotheus Hermes, William Hogarth, Immanuel Kant, Martin Knutzen, Gottfried Wilhelm von Leibniz, Gotthold Ephraim Lessing, George Lillo, Edward Moore, Johann Gottwerth Müller, Joshua Reynolds, Samuel Richardson, John Ruskin, Joseph Spence, Laurence Sterne, J. M. W. Turner and Thomas Whately, among others. (shrink)

In a well-known footnote in Book 3 of his Treatise of Human Nature, Hume calls William Wollaston's moral theory a "whimsical system" and purports to destroy it with a few brief objections. The first of those objections, although fatally flawed, has hitherto gone unrefuted. To my knowledge, its chief error has escaped attention. In this paper I expose that error; I also show that it has relevance beyond the present subject. It can occur with regard to any moral theory which, (...) like Wollaston's, locates the wrongness of an act in a property that can reside in non-actions no less than in actions. (shrink)

Early in the eleventh of his Fifteen Sermons, Joseph Butler advances his best-known argument against psychological hedonism. Elliott Sober calls that argument Butler’s stone, and famously objects to it. I consider whether Butler’s stone has philosophical value. In doing so I examine, and reject, two possible ways of overcoming Sober’s objection, each of which has proponents. In examining the first way I discuss Lord Kames’s version of the stone argument, which has hitherto escaped scholarly attention. Finally, I show that Butler’s (...) stone does something important, which I have not found previously discussed. Butler’s stone blocks an inference, persuasive to many people, which purports to show that we intrinsically desire only pleasure. (shrink)

Discussions of moral relativism commonly distinguish between normative relativism (NR) and moral judgment relativism (MJR) without highlighting the differences between the two. One significant difference—a difference between normative relativism and the most prevalent type of moral judgment relativism—is not immediately obvious and has not been discussed in print. This paper explains it and draws out some of its philosophical consequences.

When there is a conflict between parents and the physician over appropriate care due to an infant whose decision prevails? What standard, if any, should guide such decisions?This article traces the varying standards articulated over the past three decades from the proposal in Duff and Campbell’s 1973 essay that these decisions are best left to the parents to the Baby Doe Regs of the 1980s which required every life that could be salvaged be continued. We conclude with support for the (...) policy articulated in the 2007 guidelines of the American Academy of Pediatrics on non-intervention or withdrawal of intensive care for high-risk newborns. (shrink)

Scientific anomalies are observations and facts that contradict current scientific theories and they are instrumental in scientific theory change. Philosophers of science have approached scientific theory change from different perspectives as Darden (Theory change in science: Strategies from Mendelian genetics, 1991) observes: Lakatos (In: Lakatos, Musgrave (eds) Criticism and the growth of knowledge, 1970) approaches it as a progressive “research programmes” consisting of incremental improvements (“monster barring” in Lakatos, Proofs and refutations: The logic of mathematical discovery, 1976), Kuhn (The structure (...) of scientific revolutions, 1996) observes that changes in “paradigms” are instigated by a crisis from some anomaly, and Hanson (In: Feigl, Maxwell (eds) Current issues in the philosophy of science, 1961) proposes that discovery does not begin with hypothesis but with some “problematic phenomena requiring explanation”. Even though anomalies are important in all of these approaches to scientific theory change, there have been only few investigations into the specific role anomalies play in scientific theory change. Furthermore, much of these approaches focus on the theories themselves and not on how the scientists and their experiments bring about scientific change (Gooding, Experiment and the making of meaning: Human agency in scientific observation and experiment, 1990). To address these issues, this paper approaches scientific anomaly resolution from a meaning construction point of view. Conceptual integration theory (Fauconnier and Turner, Cogn Sci 22:133–187, 1996; The way we think: Conceptual blending and mind’s hidden complexities, 2002) from cognitive linguistics describes how one constructs meaning from various stimuli, such as text and diagrams, through conceptual integration or blending. The conceptual integration networks that describe the conceptual integration process characterize cognition that occurs unconsciously during meaning construction. These same networks are used to describe some of the cognition while resolving an anomaly in molecular genetics called RNA interference (RNAi) in a case study. The RNAi case study is a cognitive-historical reconstruction (Nersessian, In: Giere (ed) Cognitive models of science, 1992) that reconstructs how the RNAi anomaly was resolved. This reconstruction traces four relevant molecular genetics publications in describing the cognition necessary in accounting for how RNAi was resolved through strategies (Darden 1991), abductive reasoning (Peirce, In: Hartshorne, Weiss (eds) Collected papers, 1958), and experimental reasoning (Gooding 1990). The results of the case study show that experiments play a crucial role in formulating an explanation of the RNAi anomaly and the integration networks describe the experiments’ role. Furthermore, these results suggest that RNAi anomaly resolution is embodied. It is embodied in a sense that cognition described in the cognitive-historical reconstruction is experientially based. (shrink)

The question "Why should I be moral?," taken as a request for reasons to be moral, strikes many philosophers as silly, confused, or otherwise out of line. Hence we find many attempts to dismiss it as spurious. This paper addresses four such attempts and shows that they fail. It does so partly by discussing various errors about reasons for action, errors that lie at the root of the view that "Why should I be moral?" is ill-conceived. Such errors include the (...) mistake of confusing different uses of "moral reason for A to ø" and the mistake of treating as axiomatic, as in need of no argument, the view that moral considerations furnish every agent with practical reasons. Among the philosophers discussed are John Hospers, Philippa Foot, Stephen Toulmin, H. A. Prichard, and William Frankena. (shrink)

This study examines the relationship between an employee's level of moral reasoning and a form of work performance known as organizational citizenship behaviors (OCB). Prior research in the public accounting profession has found higher levels of moral reasoning to be positively related to various types of ethical behavior. This study extends the ethical domain of accounting behaviors to include OCB. Analysis of respondents from a public accounting firm in the northeast region of the United States (n = 107) support a (...) positive and significant relationship between moral reasoning and two dimensions of OCB: interpersonal helping behaviors and sportsmanship behaviors. This study controls for previously identified determinants of OCB (e.g., procedural justice) and demographic variables (age, sex, tenure and social desirability). Results suggest that moral reasoning accounts for professional behaviors that are perceived as intrinsically good by the employee and economically beneficial by the employer. (shrink)

A major challenge in biology is to explain why some groups have thousands or millions of species whereas others have few. Here, I review the causes of this variation. New studies reveal that higher species numbers in many major groups are explained by higher diversification rates (and traits that accelerate these rates). These traits span most of biology (e.g. genomics, ecology, morphology). Rather than simply testing individual traits, research should now focus on comparing how much variation in diversification rates is (...) explained by different types of traits. For example, is local‐scale ecology (e.g. microhabitat, diet) more important than large‐scale climate (e.g. occurring in tropical vs. temperate regions)? Are traits based on particular values (e.g. smaller body sizes) more important than those based on rates of change (e.g. faster size evolution)? I review recent results on the relative importance of different traits for driving diversification, and present a framework for future research. (shrink)